In addition, the co-stimulatory molecule CD86 was upregulated in both CD11c+MHC-IIhiCD26+XCR1+CD172a− cDC1 and CD11c+MHC-IIhiCD26+CD172a+XCR1− cDC2 in the tumor-draining lymph node (Additional file 1: Figure S2C-D). This evidence concerns the gene MPPE1 and neoplasm.