We identified, and replicated, evidence of differential regulation in proteins related to innate and adaptive immunity (CD200, CHIT1, MMP-9, MMP-10, oncostatin-M, STAMBP), membrane phospholipids (LDLR), axon guidance, cell adhesion and differentiation (ALCAM, RGMB, ROBO2), ischemic injury (uPA, tPA, SMOC2), mTOR and Wnt/β-catenin signaling (AXIN1, EIF4EBP1), and glucose metabolism (HAGH) in early and later-stage AD. Here, PLAT is linked to Alzheimer disease.