CHIT1 and Alzheimer disease: Between fluids, moderate-to-strong, positive correlations were observed for 14 proteins in CSF and their corresponding analogs in plasma, including CHIT1, which was significantly up-regulated in our primary univariate analysis of patients with AD-dementia and Aβ+ MCI versus Aβ- controls (0.5 < r < 0.73; q < 1 × 10− 61).