Our study highlights the changes and potential contributions of several chemokines (CXCL1, CCL3, CXCL5, CXCL6, CCL3, CCL19), interleukins (IL8, IL6-RA, IL18-BP), and other immune markers (OSM, ALCAM, OPG, CHIT1, YKL-40, STAMBP, MMP-9, MMP-10) in the prodromal and dementia phases of AD. This evidence concerns the gene CXCL6 and Alzheimer disease.