Furthermore, the protein level of apoptosis inducing factor (AIF) and Cytochrome C in the cytoplasm was increased at earlier time points, suggesting that mitochondrial apoptosis pathway was activated in DLBCL cells after 19S cysteine DUB inhibition by b-AP15 (Fig. 2c). The gene discussed is AIFM1; the disease is diffuse large B-cell lymphoma.