Furthermore, both SIS3 HCl and TP0427735 HCl (TGFβ/Smad signaling inhibitors) exhibit a suppression function on both p-Smad 2/3 protein level (Fig. 4f) and cell migration (Fig. 4g) in DLBCL cells, indicating that inhibiting TGFβ/Smad pathway could inhibit cell migration of DLBCL cells, which is similar to b-AP15 function. The gene discussed is TGFB1; the disease is diffuse large B-cell lymphoma.