ASPH directly interacts with Notch/JAGs and ADAM10/17, subsequently activates Notch signaling pathway, instructs synthesis/secretion of pro-oncogenic exosomes in an attempt to prepare pre-metastatic niche, through enhancing EMT, 3-D invasion, angiogenesis (tube formation), stemness (mammosphere formation and cancer stem cell markers upregulation), transendothelial migration (intravasation/extravasation) and eventual metastatic colonization/outgrowth at distant sites,. The gene discussed is ADAM10; the disease is cancer.