Therefore, we believe the 30-min prediction horizon used in this study would be adequate for alarming people with type 1 diabetes to take carbohydrate or for alarming a bihormonal AP system to infuse glucagon, but the 30-min prediction horizon might be inadequate for prevention of hypoglycemia only by reduction of insulin infusion rate in single hormone AP system. The gene discussed is GCG; the disease is Hypoglycemia.