In addition, in DLBCL patients who received R-CHOP (n = 59), high expression of CD68 or CD163 had significantly poorer OS and PFS than those with low expression of CD68 or CD163 (CD68: median OS: 23 vs 50 months, P<0.001; median PFS: 12 vs 33 months, P<0.001; CD163: median OS: 23 vs 54 months, P<0.001; median PFS: 14 vs 36 months, P<0.001). The gene discussed is CD68; the disease is diffuse large B-cell lymphoma.