The RISC and Beta-JUDO Investigators who introduced SPISE in 2016 have performed ROC analyses comparing the insulin clamp test M/I with either SPISE-IR, the fasting resistance index QUICKI-IR, or the fasting resistance index HOMA-IR (23), thus specifying insulin resistance among the total distribution of the insulin index (35,36). This evidence concerns the gene INS and Insulin resistance.