Recently, it was reported that in patients, EGF-R was expressed on myeloid cells within intestinal tumors and that in mice, EGF-R on myeloid cells but not on intestinal epithelial cells promoted colitis associated cancer in the AOM/DSS model and tumorigenesis in the APCmin/+ model and protects from colitis in an independent fashion [141]. This evidence concerns the gene EGFR and cancer.