The squalene epoxidase was found to accumulate in the liver affected by NAFLD, and is associated with poor survival in patients with HCC [107] and analogues of an enzyme of the classic pathway of bile acid synthesis from cholesterol, the fibroblast growth factor 19, which are demonstrated to reduce liver-fat content, inflammation and fibrosis in patients with NASH [108,109]. This evidence concerns the gene SQLE and metabolic dysfunction-associated steatohepatitis.