Moreover, high blood pressure and impaired vascular endothelium-dependent vasodilation were prevented by L. fermentum as a result of reduced eNOS phosphorylation at the inhibitory site Thr495, and decreased NADPH oxidase activity, commonly considered as the main source of reactive oxygen species in the vascular system, which improved the bioavailability of nitric oxide [29] (Figure 3). Here, NOS3 is linked to hypertensive disorder.