Recently, Manfredo-Vieira et al. [31] have shown how Enterococcus gallinarum is able to translocate from bowel to liver and activate the production of anti-dsDNA antibodies through TLR-7/8 activation in genetically predisposed hosts ((NZW × BXSB) F1 mice, and SLE patients). This evidence concerns the gene TLR7 and systemic lupus erythematosus.