Interestingly, 43% of detected HMGB1 interactome targets (10 of a total of 28, referenced in Table 1 and Table 3) as well as 64% of HMGB2 (7 of a total of 11, referenced in Table 2 and Table 4) have previously been related to PCa, supporting the functional significance of our Y2H interactome data in PCa research. This evidence concerns the gene HMGB2 and posterior cortical atrophy.