In summary, YY1 is a recognized prostate cancer driver [66] and different complexes in which YY1 takes part can induce activation or repression of gene expression, including also AR-YY1-mediated PSA transcription [102], which we found is also regulated by HMGB1 and HMGB2 silencing. The gene discussed is KLK3; the disease is Familial prostate cancer.