TYK2 and hematopoietic and lymphoid system neoplasm: Primary hematological neoplasm (ALCL, anaplastic large cell lymphoma; T-ALL, T cell acute lymphoblastic leukemia) patient samples and cell lines were shown to be dependent on TYK2 activated by upstream IL-10 and/or IL-22 signals and established an upregulation of anti-apoptotic BCL2 family members via STAT1 and/or STAT3 [52,53].