This finding might appear in apparent contradiction with previous lines of evidence showing an effect of this compound in lowering TNF-α in monocytes and macrophages [45], as well as in the brain of animal models of neurodegenerative disorders, such as Alzheimer’s disease [116,117], amyotrophic lateral sclerosis [42] and Parkinson’s disease [50]. This evidence concerns the gene TNF and early-onset autosomal dominant Alzheimer disease.