CYBB and psychotic disorder: In particular, enhanced levels of NOX1 enzyme have been reported in neuropsychiatric diseases characterized by psychotic symptoms [29,30], and increased NOX2 expression was observed in specific brain regions, such as the prefrontal cortex and nucleus accumbens of environmental [19,31,32] and pharmacologic rodent models of psychosis, including the one obtained by ketamine administration in adult mice [33,34,35].