The recent discovery of widespread expression of PDL-1 and PDL-2 on HRS cells and reactive cells of the microenvironment, and concomitant PD-1 upregulation on the surface of intratumoral T cells, has paved the way for checkpoint blockade and many other immunotherapy-based trials in relapsed/refractory cHL. The gene discussed is CD274; the disease is classic Hodgkin lymphoma.