NOS2 and myeloid sarcoma: An “in vitro oligodendrocyte + microglia” model of MS showed the effects of LPS in decreasing oligodendrocyte myelin production via microglia activation, which increased inducible nitric oxide synthase (iNOS) and nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase), leading to an increase in oxidative and nitrosative stress (O&NS), especially via peroxynitrite (ONOO-) [23].