Concerning HCC, data related to alteration in DNA methylation of different genes including TP53, tumor protein p16 (p16), Adenomatous Polyposis Coli (APC) regulator of WNT signalling pathway, serine peptidase inhibitor, kunitz type 2 (SPINT2), secreted frizzled related protein 1 (SFRP1), tissue factor pathway inhibitor 2 (TFPI2), GSTP1 and Ras association domain family 1 isoform A (RASSF1A) have been reported, and these patterns were often associated with cancer initiation and progression [27]. The gene discussed is TFPI2; the disease is cancer.