Sequence alterations detected globally to date in the ctDNA of patients with HCC were in genes involved in the maintenance of telomeres (i.e., TERT), in the tumor suppression (i.e., TP53), and in the regulation of cell growth and adhesion (i.e., CTNNB1) [1,42,43,44]. This evidence concerns the gene CTNNB1 and hepatocellular carcinoma.