Sequence alterations detected globally to date in the ctDNA of patients with HCC were in genes involved in the maintenance of telomeres (i.e., TERT), in the tumor suppression (i.e., TP53), and in the regulation of cell growth and adhesion (i.e., CTNNB1) [1,42,43,44]. The gene discussed is TERT; the disease is hepatocellular carcinoma.