Lu et al. [45] conducted a study to detect thecorrelation of MTHFR rs9651118 with susceptibility to breast cancer(BC), and the results suggested that rs9651118 CC genotype decreased the risk of BC.Additionally, in Caucasians, Swartz et al. [46] reported that this variant might be a factor that decreased thesusceptibility of lung cancer. Here, MTHFR is linked to breast cancer.