Previous investigationshave focused on the relationship between MTHFR haplotypes of thesetagging SNPs and cancer susceptibility; however, MTHFRGrs1801133Trs3753584Grs4845882Ars4846048Trs9651118was not found to be associated with the risk of non-small cell lung cancer [50] and esophagogastric junction adenocarcinoma[47]. This evidence concerns the gene MTHFR and gastroesophageal junction adenocarcinoma.