The BCP-ALL models were enriched for alterations in the RAS pathway (KRAS mutated in 30%, NRAS mutated in 18%) and the JAK-STAT pathway (JAK2/3 altered in 15%), and 15% have altered KMT2D. These pathways, along with PI3K/AKT, TNFα, and TP53 signaling, were all significantly enriched in gene expression data (Figure 5B). This evidence concerns the gene JAK2 and acute lymphoblastic leukemia.