Despite the overwhelming preclinical evidence that rapamycin or other inhibitors of the mTOR pathway may slow the progression of AD and several clinical trials that suggest these medications are well tolerated in older adults, there has not yet been a clinical trial testing rapamycin as a therapeutic to delay or slow disease progression in patients with AD (Kaeberlein & Galvan, 2019). The gene discussed is MTOR; the disease is Alzheimer disease.