Decreased brain perfusion during normative aging has been established (Melamed, Lavy, Bentin, Cooper, & Rinot, 1980), and we recently showed that mTOR mediates cerebrovascular dysfunction in two different mouse models of AD (Lin et al., 2017, 2013) and in a model of cognitive impairment associated with atherosclerosis (Jahrling et al., 2018). This evidence concerns the gene MTOR and Alzheimer disease.