Together with our previous studies, these data indicate that mTOR drives cerebrovascular dysfunction both in normative aging and in age‐associated disease states, including AD and cognitive impairment associated with vascular disease (Halloran et al., 2012; Jahrling et al., 2018; Lin et al., 2017, 2013; Van Skike et al., 2018) and thereby suggests that brain microvascular dysfunction may link aging to an increased risk of AD. The gene discussed is MTOR; the disease is Alzheimer disease.