CEACAM5 and neoplasm: Common biomarkers for RC including carcinoembryonic antigen (CEA) and tumor-associated antigens, such as cancer antigen 19-9 (CA19-9), cancer antigen 50 (CA50), and cancer antigen 72-4 (CA72-4), whose predictive significance of pre-operative levels in different tumor populations has been extensively documented in numerous studies [9–12].