The regulatory effect of lncRNA in CRC is closely related to the regulation of a variety molecular signalings, such as phosphoinositide 3-kinase (PI3K)/Akt [12], Wnt/β-catenin [13], nuclear factor-kappa B (NF-κB) [14], and transforming growth factor β (TGF-β)/Smad [15]. Here, TGFB1 is linked to colorectal carcinoma.