Previous studies have demonstrated that blocking of TGF-β signaling contributes to the anti-tumor effects of various lncRNAs, such as lncRNA antisense non-coding RNA in the INK4 locus (ANRIL) [18], inactive X specific transcripts (XIST) [19], activated by TGF-β (ATB) [20], TGF-β induced lncRNA (TBILA) [21], and Smad7 [22]. The gene discussed is TGFB1; the disease is neoplasm.