SNHG1 and cancer: It has been well-established in cancer biology that SNHG1 can regulate cancer cell behaviors by sponging multiple miRNAs, such as miR-145, miR-195, miR-338, and miR-497 [21–25], which are critical players in the differentiation of osteoblast and osteoclast and dysregulation of these miRNAs is correlated with bone loss and osteoporosis [26].