MUC1 and neoplasm: Indomethacin alone and MUC1 peptide vaccine alone resulted in a significantly reduced tumor burden compared to the untreated control mice starting at day 24 p.t.i. However, combining vaccine + indomethacin treatment resulted in a significant decrease in tumor growth compared to the untreated control mice starting at day 17 p.t.i. The decrease in tumor growth in the combinational therapy mice was significantly greater than that of the mice treated with indomethacin alone or vaccine alone, starting at day 20 p.t.i. (Fig 2C).