Once breast tumors had developed in these mice, we treated them with the MUC1 vaccine in combination with a COX-1 and COX-2 inhibitor (indomethacin), a specific COX-2 inhibitor (celecoxib), an IDO inhibitor (1-MT) and a PGE2 receptor antagonist (AH6809) [45]. This evidence concerns the gene PTGS2 and breast neoplasm.