In a previous study [9] we observed that the control or vehicle treated T2DM male mice and testosterone treated T2DM male mice did not show any significant change (p-value> 0.1) in the serum levels of the key glucose homeostatic hormones and cytokines like insulin, glucagon, C-peptide, leptin, GLP-1 Il-6, MCP-1 and TNFα; and thus, the testosterone mediated improvement in glycemic control in T2DM male mice is due to the alteration in signaling pathways in the tissues involved in glycemic control. The gene discussed is LEP; the disease is type 2 diabetes mellitus.