EDN1 and steatosis: Hepatic overexpression of thromboxane synthase and endothelin-1 were found and the authors suggested sinusoidal endothelial dysfunction as main mechanism responsible for increased intrahepatic vascular resistance.[14] Moreover, a recent animal model confirmed elevated portal pressure and hyperdynamic systemic circulation in a rat-model with severe steatosis.[15] Human evidence for an impact of ‘simple’ steatosis on portal pressure is limited to a small study including non-cirrhotic NAFLD patients reporting an association of steatosis and elevated portal pressure.