Regarding KEGG pathway functions associated with the feather follicles, significant differences were found in the following signaling pathways: calcium, PI3K-Akt, mTOR, cAMP, MAPK, Wnt, cGMP-PKG, Jak-STAT and adrenergic signaling in cardiomyocytes, melanogenesis, tyrosine metabolism, and melanoma. The gene discussed is AKT1; the disease is melanoma.