The PPMI study also failed to show an association with ApoA1 and motor decline, albeit over a very short period of only 12 months, which may be too short to detect differences.42 Another incident PD cohort showed similar proinflammatory response markers in the serum of incident PD subjects.31 They also found that higher CRP predicted faster rates of change in UPDRS‐III over a 3‐year period, which we failed to replicate in our own cohort. The gene discussed is CRP; the disease is Parkinson disease.