In our study, the results here indicated that LHPP was markedly reduced in AFP‐NHCC cancer tissues, consistent with previous studies by Hindupur et al.9 Targetscan, miRanda, miRDB, and TangetMiner software combined with luciferase reporter detection indicated that miR‐363‐5p and miR‐765 were involved in the targeted regulation of LHPP. Here, LHPP is linked to cancer.