SCN1A and Dravet syndrome: First, we employed a heterozygous Scn1a+/− mouse model lacking one copy of the NaV1.1 protein (Thiele et al., 2018) that is used as a model for a variety of seizure types from simple febrile seizures to severe genetic disorders such as Dravet (Nakayama et al., 2018) and Lennox–Gastaut syndromes (Zhou et al., 2018).