SCN1A and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy: Employing a mouse Scn1a+/− mutant to investigate a potential mechanism of CBD provided a logical approach, as this model reproduces seizure types found in patients with Dravet syndrome (Marini et al., 2011) and Lennox–Gastaut syndrome (Selmer et al., 2009).