Therefore, with the expectation to provide better treatment modalities for TC patients, the present study investigated the effect of LINC01296 on TC, and revealed that LINC01296 could competitively bind to miR-143-3p to down-regulate MSI2, and that silencing LINC01296 could inhibit the tumor progression of TC by blocking the AKT/STAT3 signaling pathway. The gene discussed is STAT3; the disease is neoplasm.