The identification of the procoagulant potential of cancer cells, principally mediated from tissue factor (TF), attracts particular interest since it is closely related with cancer aggressiveness, proangiogenic properties, resistance to anticancer treatment, and metastatic potential.3Enhanced fibrin formation as well as clots with low permeability and resistant to lysis have been observed in patients with multiple myeloma.4Myeloma plasma cells (MPCs) are potential initiators of the process leading to hypercoagulability. Here, TF is linked to cancer.