KLK6 and neoplasm: When this analysis was stratified according to the status of the K-RAS oncogene in the primary tumor, a significant increase in the KLK6 staining score was observed in the luminal surface and crypts of the non-cancerous tissues 10 cm away from the primary tumors positive for K-RAS mutation (Table 1B, p = 0.045 and p = 0.0515, respectively).