KRAS and colorectal carcinoma: Our analysis of KLK6 expression in CRC patients by IHC shows the statistically significant increase in the staining score for KLK6 protein in the morphologically normal tissue 10 cm away from tumors, which were tested positive for K-RAS mutation (p = 0.05 for crypts staining and p = 0.0445 for luminal surface area).