Hence, we acknowledge that a limitation of the current study is that we have not addressed whether changes in vascular cell TRIB1 expression might affect early-stage atherosclerosis development and whether the GWAS-CHD signal at the TRIB1 locus reflects that, in these cells (and hepatocytes), TRIB1 serves an atheroprotective role, in contrast to the situation in plaque-resident macrophages, where it induces foam cell expansion. The gene discussed is TRIB1; the disease is atherosclerosis.