TRIB1 and coronary artery disorder: Despite the success in establishing that hepatic Trib1 expression affects the regulation of multiple cellular processes modulating blood cholesterol and triglyceride levels (15), the influence of global-KO of Trib1 on shaping the phenotype of macrophages (16), and the finding that variants at the TRIB1 locus are associated with and increased coronary heart disease (CHD) risk (14), the contribution of Trib1 on atherogenesis remains to be addressed.