NCEH1 and atherosclerosis: These would include, for example, beneficially increasing NCEH1 expression to reduce the release of proinflammatory cytokines from plaque-resident macrophages (32), while reducing the expression of LPL to help reduce the retention of LDL in the artery wall during early-stage atherosclerosis (7), as well as excessive accumulation of cholesteryl ester and triglycerides within macrophage foam cells (8).