FLT3 and acute myeloid leukemia: Given that a previous study showed that FLT3wt was responsible for inducing the FL-dependent attenuation of the growth inhibitory effect of quizartinib [26], we investigated the growth inhibitory effects of quizartinib and midostaurin using the human AML cell line MV4-11, which harbors a homozygous FLT3-ITD mutation.