We further found two significantly dysregulated microRNA-mediated gene expression alterations in endometrial adenocarcinoma: downregulated hsa-miR-127-5p with upregulated CSTB and upregulated hsa-miR-218-5p with downregulated HPGD. These findings may contribute important new insights into possible novel diagnostic or therapeutic strategies for endometrial cancer. This evidence concerns the gene HPGD and endometrial cancer.