We report that EMPD expresses high levels of B7 family members B7-H3 and B7-H4 with lower levels of CTAs MAGE-A and NY-ESO-1, very focal expression of PD-L1, and no expression of PD-L2 in addition to high levels of antigen presenting machinery molecules B2M and MHC-I in this cohort. The gene discussed is B2M; the disease is extramammary Paget disease.