Among the invasive tumor component, 2 (9.5%) of 21 were B7-H3/B7-H4/PD-L1 triple positive, 10 (47.6%) of 21 were B7-H3/B7-H4 double positive, 3 (14.3%) of 21 were B7-H3 single positive, and 1 (4.8%) of 21 were B7-H4 single positive (Figure 5B). The gene discussed is CD274; the disease is neoplasm.