Among the in situ tumor component, 3 (6.1%) of 49 were B7-H3/B7-H4/PD-L1 triple positive, 36 (73.5%) of 49 were B7-H3/B7-H4 double positive, 7 (14.3%) of 49 were B7-H3 single positive, and 1 (2.0%) of 49 were B7-H4 single positive overall (Figure 5A). The gene discussed is CD80; the disease is neoplasm.