Among the invasive component of EMPD tumors, higher B2M, MHC-I, MAGE-A, and CK20 and no B7-H4 and PD-L1 expression was observed in tumors of secondary origin localized in the perianal region (Figure 3B) compared to primary cutaneous EMPD. This evidence concerns the gene KRT20 and extramammary Paget disease.