We then performed hierarchical clustering of tumor cell immunohistochemical (IHC) expression scores and correlated these findings with multiple characteristics of the tumor including sex, extent of disease, origin, anatomic site, prior treatment, CK7/CK20 status, vital status, and CD8 density within a series of predominantly in situ and invasive EMPD. The gene discussed is KRT7; the disease is extramammary Paget disease.