TP53 and metastatic neoplasm: We identified several other significant correlations of potential clinical importance on pairwise comparisons (Table 3): history of diabetes with CDK (positive correlation) or replicative stress pathway alterations (negative correlation), age >54 with non-metastatic disease, ERCC1 expression (IHC) with DAXX or MEN1 alterations (NGS), and PTEN (NGS) with ARID1A or TP53 alterations (NGS).