VEGFA and rheumatoid arthritis: When we analyzed associations between the 5 VEGF-C SNPs and age of RA onset, we found a significantly protective effect for the heterozygous genotype (C/T) of SNP rs7664413 for the development of RA disease before 35 years of age, which was also the case for patients who had the A/G genotype of rs2046463 (p = 0.02 for each comparison with the wild-type genotypes of each polymorphism).