DLBCL is an example of such a disease where cell death resistance depends upon combinations of BIM bound to a number of antiapoptotics (BCL-2, BCL-XL, and MCL-1), and is therefore a useful model for testing the importance of both anti-apoptotic expression and BIM:anti-apoptotic sequestration differences relating to BH3-mimetic sensitivity [10–12, 25]. Here, MCL1 is linked to diffuse large B-cell lymphoma.