INS and Insulin resistance: The use of CGM enabled us to assess 24-h glycemic profiles during both MDI and IDD in-clinic periods.24 Prior studies have used CGM to evaluate glycemic measures with insulin pump therapy for T2D; however, these studies have not assessed the use of RHI.25–28 Lane et al.29 used periodic 72-h CGM during their 1-year study of 20 patients with severe insulin-resistant T2D who were administered U500 insulin by CSII.