Tumor cells harboring these two mutations accumulated quickly along with many other mutations, including an important mutation of NTRK3. The mutations, c.1585+4193C>G in the intron of NTRK3 and p.Asn41fs in the exon 2 of B2M, had a similar trend between day 86 and 149, suggesting that the latter mutation was likely within the former clones. This evidence concerns the gene NTRK3 and neoplasm.