Notably, reduced CerS1 and CerS5 mRNA expression was observed in chronically ill patients suffering from chronic heart failure (Figure 2), suggesting that decline of CerS1 and CerS5 gene expression is functionally relevant for the development of critical illness‐associated myopathies (Latronico & Bolton, 2011; Saitoh et al., 2017). Here, CERS5 is linked to congestive heart failure.