A previous study demonstrated that the CD244 signaling pathway exhibited a positive correlation with high expression levels of lncRNA‐BC050410 in CD8+ T cells stimulated during MTB infection.24 Another study demonstrated that the expression levels of two lncRNAs, namely MIR3945HG V1 and MIR3945HG V2 were significantly elevated in the pulmonary tuberculosis patients compared with those noted in the healthy controls.25 These findings indicated that lncRNAs could affect the susceptibility of TB by specific mechanisms of action. This evidence concerns the gene CD8A and tuberculosis.