LDLR and familial hyperaldosteronism: Dyslipidemia: Hypercholesterolaemia increases the risk of developing lower extremity PAD by 90% (p = 0.05).493 FH is an autosomal dominant condition associated with mutations in the LDL receptor-encoding gene or ApoB and PCSK-C coding genes.9 In a Brazilian cross-sectional study, 202 patients with heterozygous FH were compared to 524 normolipidemic controls.