Several scoring systems determine the serious process of disease by evaluation of clinical and laboratory results: APACHE‐II (Bezmarević et al., 2012), Ranson score (Aphinives et al., 2011; Tan et al., 2017), improved Glasgow‐Imrie criteria (Tan et al., 2017), SIRS standard, bedside index of AP severity and noninvasive AP score (Gao, Yang and Ma, 2015), whereas CRP might also be used as an indicator of disease severity (Zheng, Zhang and Gao, 2015). This evidence concerns the gene CRP and alkaline phosphatase measurement.