We noted that NRAS, PAK2 EGFR and PAK1 were enriched in the MAPK signalling pathway, through which MEL may regulate tumour cells and influence their biological behaviour, as previously reported.34, 35 Module 2 was composed of the ATP6V0B, ATP6V1C1, ATP6V1E2, ATP6V0C, ATP6V1F and ATP6V0A2 genes, partly constituting the V‐ATPase domain. The gene discussed is PAK1; the disease is neoplasm.