CDKN1A and Familial prostate cancer: In consistent with our reports, in androgen receptor‐transformed PC3 prostate cancer, MYST1 depletion also induces p21 upregulation, which results in G2M arrest.56 Other study also showed that MYST1/MOF directly binds and maintains the expression of genes required for cell cycle progression in proliferating cells.15 Besides, in the mini ontology analysis, DNA repair, which might be a reason for G2M phase arrest, was the third most related biological process (Figure 3A).