In fact, circulating tumor DNA (ctDNA) demonstrates high accuracy in the analysis of EGFR mutation status, but its sensitivity is relatively low.3, 5, 6, 7 The sensitivity of ctDNA ranges between 70.0% and 75.0%, and a possible explanation is that the ability to detect gene mutations in plasma ctDNA is related to tumor load; for patients with a smaller tumor load, the false‐negative rate will increase significantly. This evidence concerns the gene EGFR and neoplasm.