The reason for this may be that pleural effusion overcomes tumor heterogeneity to some extent.16 The present study systematically analyzed the differential expression levels of lncRNAs in the pleural effusions of three EGFR‐mutant patients and three EGFR wild‐type patients with NSCLC, detected the relative expression levels in pleural effusions and plasma through qRT‐PCR, and comprehensively evaluated the potential of SCARNA7, MALAT1, and NONHSAT017369 as prospective markers for EGFR mutation status in patients with NSCLC. Here, MALAT1 is linked to neoplasm.