LncRNAs with high expression and known biological functions in lung cancer have been previously described and include MALAT1,27, 28 HOTAIR, Gas5, and H1929, 30, 31 Most of these lncRNAs are involved in the important biological regulation mechanism of the cancer occurrence, development, invasion and metastasis, and play an important regulatory role in lung cancer cells. This evidence concerns the gene HOTAIR and lung carcinoma.