Conversely, when MIR32 inhibited its target gene KLF4, the overexpression of SNHG5 could partially prevent MIR32 function.31 Moreover, Zhao et al found that upregulation of SNHG5 could prevent MTA2 locating to the nucleus from the cytoplasm, and inhibit gastric cancer cell migration and invasion.69 They also found that when SNHG5 was overexpressed, the protein levels of MMP2, MMP9 and EGFR were reduced, while CDH1 and CDKN1A were upregulated.69 The gene discussed is MMP9; the disease is gastric cancer.