Increased GAS5 was an independent marker of a longer overall survival and better prognosis.43, 45Yuan et al found that co‐overexpressed GAS5 and SNORD44 could significantly repress tumor growth and they could induce cancer cells apoptosis in both vivo and vitro.46 The overexpression of GAS5 could suppress colon cancer cells proliferation and promote apoptosis by inhibiting the expression of MIR‐182‐5p and MIR‐221, but upregulating FOXO3a. 43, 44. This evidence concerns the gene GAS5 and colonic neoplasm.