PTEN and cancer: The PIK3CA/AKT signaling pathway was activated when SNHG1 was overexpressed.39 Gao et al put forward that GAS5 reduced the drug resistance of cancer cells through regulating MIR‐181c‐5p and Hippo pathway.113 Moreover, GAS5 could downregulate MIR‐32‐5p and increase the PTEN protein level.114SNHG9 was expressed at a lower level in cancer tissues and serum than in normal tissues, and there were negative correlations with cancer stage, lymph node metastasis, disease prognosis.