On the contrary, reduced expression of GAS5 was associated with poor differentiation, advanced TNM stage, tumor size, lymph node metastasis and acted an independent poor prognosis marker for liver cancer.87, 88GAS5 could downregulate MIR21 to prevent cancer cell migration and invasion.89 Chang et al indicated that GAS5 repressed cell proliferation by means of reducing VIM, increasing CDH1 and influencing EMT pathway.90 Here, GAS5 is linked to cancer.